The challenge of classifying metastatic cell properties by molecular profiling exemplified with cutaneous melanoma cells and their cerebral metastasis from patient …
B Neuditschko, L Janker, L Niederstaetter… - Molecular & Cellular …, 2020 - ASBMB
The prediction of metastatic properties from molecular analyses still poses a major
challenge. Here we aimed at the classification of metastasis-related cell properties by
proteome profiling making use of cutaneous and brain-metastasizing variants from single
melanomas sharing the same genetic ancestry. Previous experiments demonstrated that
cultured cells derived from these xenografted variants maintain a stable phenotype
associated with a differential metastatic behavior: The brain metastasizing variants produce …
challenge. Here we aimed at the classification of metastasis-related cell properties by
proteome profiling making use of cutaneous and brain-metastasizing variants from single
melanomas sharing the same genetic ancestry. Previous experiments demonstrated that
cultured cells derived from these xenografted variants maintain a stable phenotype
associated with a differential metastatic behavior: The brain metastasizing variants produce …
