[HTML][HTML] Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1: a potential mechanism for …
DA Antonetti, AJ Barber, LA Hollinger… - Journal of Biological …, 1999 - ASBMB
Vascular endothelial growth factor (VEGF) may have a physiologic role in regulating vessel
permeability and contributes to the pathophysiology of diabetic retinopathy as well as tumor
development. We set out to ascertain the mechanism by which VEGF regulates paracellular
permeability in rats. Intra-ocular injection of VEGF caused a post-translational modification of
occludin as determined by a gel shift from 60 to 62 kDa. This event began by 15 min post-
injection and was maximal by 45 min. Alkaline phosphatase treatment revealed this …
permeability and contributes to the pathophysiology of diabetic retinopathy as well as tumor
development. We set out to ascertain the mechanism by which VEGF regulates paracellular
permeability in rats. Intra-ocular injection of VEGF caused a post-translational modification of
occludin as determined by a gel shift from 60 to 62 kDa. This event began by 15 min post-
injection and was maximal by 45 min. Alkaline phosphatase treatment revealed this …