Ex vivo human pancreatic slice preparations offer a valuable model for studying pancreatic exocrine biology
T Liang, S Dolai, L Xie, E Winter, AI Orabi… - Journal of Biological …, 2017 - ASBMB
A genuine understanding of human exocrine pancreas biology and pathobiology has been
hampered by a lack of suitable preparations and reliance on rodent models employing
dispersed acini preparations. We have developed an organotypic slice preparation of the
normal portions of human pancreas obtained from cancer resections. The preparation was
assessed for physiologic and pathologic responses to the cholinergic agonist carbachol
(Cch) and cholecystokinin (CCK-8), including 1) amylase secretion, 2) exocytosis, 3) …
hampered by a lack of suitable preparations and reliance on rodent models employing
dispersed acini preparations. We have developed an organotypic slice preparation of the
normal portions of human pancreas obtained from cancer resections. The preparation was
assessed for physiologic and pathologic responses to the cholinergic agonist carbachol
(Cch) and cholecystokinin (CCK-8), including 1) amylase secretion, 2) exocytosis, 3) …
