Mitochondrial quality control systems are essential for the maintenance of functional
mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and
fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged
mitochondria. Specifically, in mitophagy, the target mitochondria are recognized by the
autophagosomes and delivered to the lysosome for degradation. In this review, we describe
the mechanisms of mitophagy and the factors that play an important role in this process. In …