SDF-1α regulates HIV-1-gp120-induced changes in CD79b surface expression and Ig production in activated human B cells
CL Nance, WT Shearer - Clinical Immunology, 2002 - Elsevier
Binding of HIV-1 glycoprotein (gp120) to activated B cells of HIV-infected and HIV-uninfected
subjects induces increased cell proliferation, cAMP generation, immunoglobulin (Ig)
production and downregulation of the invariant chain, CD79b, of the B-cell receptor. We
present evidence that the stromal cell-derived factor-1α (SDF-1α), itself a B-cell stimulant,
reversed gp120-driven downregulation of CD79b in CD40-and IL-4-activated purified HIV-1
seronegative human peripheral blood B cells. SDF-1α augmented gp120-induced Ig …
subjects induces increased cell proliferation, cAMP generation, immunoglobulin (Ig)
production and downregulation of the invariant chain, CD79b, of the B-cell receptor. We
present evidence that the stromal cell-derived factor-1α (SDF-1α), itself a B-cell stimulant,
reversed gp120-driven downregulation of CD79b in CD40-and IL-4-activated purified HIV-1
seronegative human peripheral blood B cells. SDF-1α augmented gp120-induced Ig …