Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating
processes related to mood and motivation. This review presents findings from the basic
neuroscience literature and from some clinically oriented research, drawing from behavioral,
neuroanatomical, electrophysiological, and molecular studies in support of such a role, and
articulates models and hypotheses intended to advance our understanding of these
functions. Neuroanatomically, the LS is connected with numerous regions known to regulate …