[HTML][HTML] Transforming Growth Factor β (TGFβ) Signaling via Differential Activation of Activin Receptor-like Kinases 2 and 5 during Cardiac Development: ROLE IN …
SM Ward, JS Desgrosellier, X Zhuang… - Journal of Biological …, 2002 - ASBMB
Little is known regarding factors that induce parasympathetic responsiveness during cardiac
development. We demonstrated previously that in atrial cells cultured from chicks 14 days in
ovo, transforming growth factor β (TGFβ) decreased parasympathetic inhibition of beat rate
by the muscarinic agonist, carbamylcholine, by 5-fold and decreased expression of Gα i2.
Here in atrial cells 5 days in ovo, TGFβ increased carbamylcholine inhibition of beat rate 2.5-
fold and increased expression of Gα i2. TGFβ also stimulated Gα i2 mRNA expression and …
development. We demonstrated previously that in atrial cells cultured from chicks 14 days in
ovo, transforming growth factor β (TGFβ) decreased parasympathetic inhibition of beat rate
by the muscarinic agonist, carbamylcholine, by 5-fold and decreased expression of Gα i2.
Here in atrial cells 5 days in ovo, TGFβ increased carbamylcholine inhibition of beat rate 2.5-
fold and increased expression of Gα i2. TGFβ also stimulated Gα i2 mRNA expression and …