Understanding the role of ETS-mediated gene regulation in complex biological processes
VJ Findlay, AC LaRue, DP Turner, PM Watson… - Advances in cancer …, 2013 - Elsevier
Ets factors are members of one of the largest families of evolutionarily conserved
transcription factors, regulating critical functions in normal cell homeostasis, which when
perturbed contribute to tumor progression. The well-documented alterations in ETS factor
expression and function during cancer progression result in pleiotropic effects manifested by
the downstream effect on their target genes. Multiple ETS factors bind to the same regulatory
sites present on target genes, suggesting redundant or competitive functions. The anti-and …
transcription factors, regulating critical functions in normal cell homeostasis, which when
perturbed contribute to tumor progression. The well-documented alterations in ETS factor
expression and function during cancer progression result in pleiotropic effects manifested by
the downstream effect on their target genes. Multiple ETS factors bind to the same regulatory
sites present on target genes, suggesting redundant or competitive functions. The anti-and …
