Neurotrophins and their receptors in breast cancer
H Hondermarck - Cytokine & growth factor reviews, 2012 - Elsevier
Growth factors of the neurotrophin family and their receptors have been mainly studied in the
nervous system, but they are also expressed in carcinomas, and in breast cancer they
significantly impact tumor cell growth and metastasis through various signaling pathways.
Nerve growth factor and its precursor proNGF, brain-derived neurotrophic factor and
neurotrophin-4/5 stimulate breast cancer cells through an autocrine loop involving the
tyrosine kinase receptors TrkA, TrkB as well as its truncated form TrkB. T1 and the p75NTR …
nervous system, but they are also expressed in carcinomas, and in breast cancer they
significantly impact tumor cell growth and metastasis through various signaling pathways.
Nerve growth factor and its precursor proNGF, brain-derived neurotrophic factor and
neurotrophin-4/5 stimulate breast cancer cells through an autocrine loop involving the
tyrosine kinase receptors TrkA, TrkB as well as its truncated form TrkB. T1 and the p75NTR …