[PDF][PDF] Licensed to ill: IL-9 generation in immature mast cells permits food-elicited anaphylaxis
NA Barrett, KF Austen - Immunity, 2015 - cell.com
NA Barrett, KF Austen
Immunity, 2015•cell.comLicensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis Page
1 T cells (Nishimura et al., 2009), and Reisner and colleagues corroborate this. Through
deconvolution of variance between groups, the authors identified TCR-b sequences which were
enriched in AT of mice lacking Perf-DCs. Several of the identified TCR-b sequences varied at
the nucleotide level while encoding synonymous codons. Enticingly, this implies Perf-DCs
constrain T cell clones, which recognize specific antigen(s) present in AT. The authors conclude …
1 T cells (Nishimura et al., 2009), and Reisner and colleagues corroborate this. Through
deconvolution of variance between groups, the authors identified TCR-b sequences which were
enriched in AT of mice lacking Perf-DCs. Several of the identified TCR-b sequences varied at
the nucleotide level while encoding synonymous codons. Enticingly, this implies Perf-DCs
constrain T cell clones, which recognize specific antigen(s) present in AT. The authors conclude …
Food-specific IgE is central to the pathobiology of food allergy, but not sufficient to induce disease. Chen et al. (2015) demonstrate that food-elicited reactions require an immature mast cell that generates IL-9 to induce its own maturation.
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