Nephrotoxicity is a major adverse effect of cisplatin-mediated chemotherapy in cancer
patients. The pathogenesis of cisplatin-induced nephrotoxicity remains largely unclear,
making it difficult to design effective renoprotective approaches. Here, we have examined
the role of microRNAs (miRNAs) in cisplatin-induced nephrotoxicity. We show that cisplatin
nephrotoxicity was not affected by overall depletion of both beneficial and detrimental
miRNAs from kidney proximal tubular cells in mice in which the miRNA-generating enzyme …