[HTML][HTML] The glycoprotein Ibα–von Willebrand factor interaction induces platelet apoptosis
S Li, Z Wang, Y Liao, W Zhang, Q Shi, R Yan… - Journal of thrombosis …, 2010 - Elsevier
Background: The interaction of glycoprotein (GP) Ibα with von Willebrand factor (VWF)
initiates platelet adhesion, and simultaneously triggers intracellular signaling cascades
leading to platelet aggregation and thrombus formation. Some of the signaling events are
similar to those occurring during apoptosis, however, it is still unclear whether platelet
apoptosis is induced by the GPIbα–VWF interaction. Objectives: To investigate whether the
GPIbα–VWF interaction induces platelet apoptosis and the role of 14‐3‐3ζ in apoptotic …
initiates platelet adhesion, and simultaneously triggers intracellular signaling cascades
leading to platelet aggregation and thrombus formation. Some of the signaling events are
similar to those occurring during apoptosis, however, it is still unclear whether platelet
apoptosis is induced by the GPIbα–VWF interaction. Objectives: To investigate whether the
GPIbα–VWF interaction induces platelet apoptosis and the role of 14‐3‐3ζ in apoptotic …
