Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis
A Pianta, EE Drouin, JT Crowley, S Arvikar, K Strle… - Clinical …, 2015 - Elsevier
In this study, autoantibody responses to annexin A2 were found in 11–15% of 278 patients
with Lyme disease, including in those with erythema migrans (EM), an early sign of the
illness, and in those with antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA), a
late disease manifestation. In contrast, robust T cell reactivity to annexin A2 peptides was
found only in patients with responsive or refractory LA. In LA patients, annexin A2 protein
levels, which were higher in the refractory group, correlated with annexin A2 antibody levels …
with Lyme disease, including in those with erythema migrans (EM), an early sign of the
illness, and in those with antibiotic-responsive or antibiotic-refractory Lyme arthritis (LA), a
late disease manifestation. In contrast, robust T cell reactivity to annexin A2 peptides was
found only in patients with responsive or refractory LA. In LA patients, annexin A2 protein
levels, which were higher in the refractory group, correlated with annexin A2 antibody levels …