The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2
diabetes, alterations in hepatic glucose metabolism are observed, ie increased post-
absorptive glucose production and impaired suppression of glucose production together
with diminished glucose uptake following carbohydrate ingestion. The simultaneous
overproduction of glucose and fatty acids in liver further stimulates the secretion of insulin by …