Type VII collagen (C7) is located in the skin between its two main layers, the epidermis and the dermis, where it forms structures, anchoring fibrils (AFs), that are necessary for epidermal-dermal adherence (Sakai et al., 1986; Burgeson, 1993)). The COL7A1 gene encodes for a 290 kDa alpha chain (Christiano et al., 1994). C7 is composed of three alpha chains that form a homotrimer of∼ 900 kDa (1). Within the extracellular space, C7 molecules form antiparallel dimers, which aggregate laterally to form AFs. C7 has some unusual properties that make it quite distinctive from other collagens, such as its solubility in neutral buffers. Most skin-associated collagens such as type I collagen induce platelet aggregation and clot formation when exposed to the blood stream while C7 does not