The curious origins of angioimmunoblastic T-cell lymphoma
JR Cortés, T Palomero - Current opinion in hematology, 2016 - journals.lww.com
JR Cortés, T Palomero
Current opinion in hematology, 2016•journals.lww.comAITL originates from follicular T helper cells and is characterized by the presence of RHOA
G17V mutation together with genetic alterations in TET2, DNMT3A, and IDH2. Research
efforts now focus on the elucidation of the specific roles and interplay of these genetic
alterations in the pathogenesis of AITL.
G17V mutation together with genetic alterations in TET2, DNMT3A, and IDH2. Research
efforts now focus on the elucidation of the specific roles and interplay of these genetic
alterations in the pathogenesis of AITL.
Summary
AITL originates from follicular T helper cells and is characterized by the presence of RHOA G17V mutation together with genetic alterations in TET2, DNMT3A, and IDH2. Research efforts now focus on the elucidation of the specific roles and interplay of these genetic alterations in the pathogenesis of AITL.
Lippincott Williams & Wilkins