[HTML][HTML] Promyelocytic leukemia protein controls cell migration in response to hydrogen peroxide and insulin-like growth factor-1

EL Reineke, Y Liu, HY Kao - Journal of biological chemistry, 2010 - ASBMB
Promyelocytic leukemia protein (PML) was originally identified as part of a chromosomal
translocation that contributes to the development of acute promyelocytic leukemia (APL).
Since its discovery, PML has been found to play diverse roles in different cellular processes.
Notably, PML has anti-proliferative and pro-apoptotic activity that supports its role as a tumor
suppressor. We have previously shown that the peptidyl-prolyl isomerase Pin1 is able to
affect cell proliferation and hydrogen peroxide (H 2 O 2)-mediated cell death through …