[HTML][HTML] Striking dichotomy of PD-L1 and PD-L2 pathways in regulating alloreactive CD4+ and CD8+ T cells in vivo

A Habicht, R Kewalaramani, MD Vu, G Demirci… - American Journal of …, 2007 - Elsevier
Programmed death-1 (PD-1) is a recently identified coinhibitory molecule that belongs to the
CD28 superfamily. PD-1 has two ligands PD-L1 and PD-L2. There is some evidence that PD-
L1 and PD-L2 serve distinct functions, but their exact function in alloimmunity remains
unclear. In the present study, we used a GVHD-like model that allows detailed analyses of T-
cell activation at a single cell level in vivo to examine the role of PD-1/PD-L1 and PD-1/PD-
L2 interactions in regulating proliferation of CD4+ and CD8+ T cells in response to …