Partial leptin deficiency and human adiposity

IS Farooqi, JM Keogh, S Kamath, S Jones, WT Gibson… - Nature, 2001 - nature.com
IS Farooqi, JM Keogh, S Kamath, S Jones, WT Gibson, R Trussell, SA Jebb, GYH Lip
Nature, 2001nature.com
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice
and humans, without it suffer from a voracious appetite and extreme obesity. The effect on
energy balance of variations in plasma leptin above a minimal threshold is uncertain,
however, particularly in humans. Here we examine a group of individuals who are
genetically partially deficient in leptin, and show that differences in circulating leptin levels
within the range found in normal human populations can directly influence the laying down …
Abstract
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans, without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically partially deficient in leptin, and show that differences in circulating leptin levels within the range found in normal human populations can directly influence the laying down of fat tissue (adiposity).
nature.com