Blockade of PD-1 immunosuppression boosts CAR T-cell therapy
LB John, MH Kershaw, PK Darcy - Oncoimmunology, 2013 - Taylor & Francis
LB John, MH Kershaw, PK Darcy
Oncoimmunology, 2013•Taylor & FrancisThe presence of an immunosuppressive microenvironment can limit the full potential of
adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive
pathway can significantly enhance the function of gene-modified T cells expressing a
chimeric antigen receptor (CAR) leading to enhanced tumor eradication.
adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive
pathway can significantly enhance the function of gene-modified T cells expressing a
chimeric antigen receptor (CAR) leading to enhanced tumor eradication.
The presence of an immunosuppressive microenvironment can limit the full potential of adoptive T cell immunotherapy. However, specific blockade of the PD-1 immunosuppressive pathway can significantly enhance the function of gene-modified T cells expressing a chimeric antigen receptor (CAR) leading to enhanced tumor eradication.
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