The secreted tumor-associated antigen 90K is a potent immune stimulator
A Ullrich, I Sures, M D'Egidio, B Jallal, TJ Powell… - Journal of Biological …, 1994 - ASBMB
Immunization of mice with conditioned media from human breast cancer cells yielded the
monoclonal antibody SP-2, which recognized an antigen of approximately 90-95 kDa. This
protein, designated 90K, was found to be present in the serum of healthy individuals and at
elevated levels in the serum of subpopulations of patients with various types of cancer and
AIDS. Here we report the primary structure of the SP-2 antigen and demonstrate its
relationship to a family of proteins which carry a scavenger receptor cysteine-rich domain …
monoclonal antibody SP-2, which recognized an antigen of approximately 90-95 kDa. This
protein, designated 90K, was found to be present in the serum of healthy individuals and at
elevated levels in the serum of subpopulations of patients with various types of cancer and
AIDS. Here we report the primary structure of the SP-2 antigen and demonstrate its
relationship to a family of proteins which carry a scavenger receptor cysteine-rich domain …