[PDF][PDF] Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer

S Wang, J Gao, Q Lei, N Rozengurt, C Pritchard, J Jiao… - Cancer cell, 2003 - cell.com
S Wang, J Gao, Q Lei, N Rozengurt, C Pritchard, J Jiao, GV Thomas, G Li, P Roy-Burman…
Cancer cell, 2003cell.com
The murine Pten prostate cancer model described in this study recapitulates the disease
progression seen in humans: initiation of prostate cancer with prostatic intraepithelial
neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent
metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after
androgen ablation, they are capable of proliferating in the absence of androgen. Global
assessment of molecular changes caused by homozygous Pten deletion identified key …
Abstract
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of prostate cancer with prostatic intraepithelial neoplasia (PIN), followed by progression to invasive adenocarcinoma, and subsequent metastasis with defined kinetics. Furthermore, while Pten null prostate cancers regress after androgen ablation, they are capable of proliferating in the absence of androgen. Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis. This murine prostate cancer model provides a unique tool for both exploring the molecular mechanism underlying prostate cancer and for development of new targeted therapies.
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