Characterisation of allergen-specific responses of IL-10-producing regulatory B cells (Br1) in Cow Milk Allergy
J Noh, JH Lee, G Noh, SY Bang, HS Kim, WS Choi… - Cellular …, 2010 - Elsevier
CD19+ CD5+ regulatory B cells regulate immune responses by producing IL-10. IL-10-
producing regulatory B cell (Br1) responses by allergen stimulation were investigated in
human food allergy. Six milk allergy patients and eight milk-tolerant subjects were selected
according to DBPCFC. PBMCs were stimulated by casein in vitro and stained for
intracellular IL-10 and apoptosis. In response to allergen stimulation, Br1 decreased from
26.2±18.3 to 15.5±8.9%(p= 0.031, n= 6) in the milk allergy group and increased from …
producing regulatory B cell (Br1) responses by allergen stimulation were investigated in
human food allergy. Six milk allergy patients and eight milk-tolerant subjects were selected
according to DBPCFC. PBMCs were stimulated by casein in vitro and stained for
intracellular IL-10 and apoptosis. In response to allergen stimulation, Br1 decreased from
26.2±18.3 to 15.5±8.9%(p= 0.031, n= 6) in the milk allergy group and increased from …