In vivo depletion of leukocytes and platelets following injection of T cell-specific antibodies into mice

L Loubaki, T Tremblay, R Bazin - Journal of immunological methods, 2013 - Elsevier
In vivo T cell depletion experiments are widely used to establish the role of these cells in a
variety of immunological processes. Different clones of monoclonal antibody targeting the
CD3 molecular complex (mainly 145-2C11 and 17A2) have been successfully used for T
cell depletion. In the present work, we assessed the specificity of monoclonal antibody-
mediated CD3 T cell depletion in mouse peripheral blood. We showed that treatment of
BALB/C mice with monoclonal antibodies (clones 145-2C11 and 17A2) not only efficiently …