[HTML][HTML] Metabolism of activated complement component C3 is mediated by the low density lipoprotein receptor-related protein/α2-macroglobulin receptor
M Meilinger, C Gschwentner, I Burger… - Journal of Biological …, 1999 - ASBMB
Complement component 3 (C3) and α 2-macroglobulin evolved from a common,
evolutionarily old, ancestor gene. Low density lipoprotein-receptor-related protein/α 2-
macroglobulin receptor (LRP/α 2 MR), a member of the low density lipoprotein receptor
family, is responsible for the clearance of α 2-macroglobulin-protease complexes. In this
study, we examined whether C3 has conserved affinity for LRP/α 2 MR. Ligand blot
experiments with human 125 I-C3 on endosomal proteins show binding to a 600-kDa …
evolutionarily old, ancestor gene. Low density lipoprotein-receptor-related protein/α 2-
macroglobulin receptor (LRP/α 2 MR), a member of the low density lipoprotein receptor
family, is responsible for the clearance of α 2-macroglobulin-protease complexes. In this
study, we examined whether C3 has conserved affinity for LRP/α 2 MR. Ligand blot
experiments with human 125 I-C3 on endosomal proteins show binding to a 600-kDa …