Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function

G Avila, RT Dirksen - Cell Calcium, 2005 - Elsevier
FK506 and rapamycin are immunosuppressant drugs that disrupt the interaction of FK506-
binding proteins (FKBPs) with ryanodine receptors (RyR1), which form homotetrameric
Ca2+ release channels in the sarcoplasmic reticulum (SR) of skeletal muscle. Here, we
characterized the effects of short-term treatment (2h) of skeletal myotubes with either 20μM
FK506 or 20μM rapamycin on excitation–contraction (EC) coupling, sarcolemmal
dihydropyridine receptor (DHPR) function, resting intracellular Ca2+, and levels of SR Ca2+ …