MicroRNA‐23b cluster microRNAs regulate transforming growth factor‐beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting …

CE Rogler, L LeVoci, T Ader, A Massimi… - Hepatology, 2009 - journals.lww.com
Transforming growth factor-beta/bone morphogenetic protein (TGFß/BMP) signaling has a
gradient of effects on cell fate choice in the fetal mouse liver. The molecular mechanism to
understand why adjacent cells develop into bile ducts or grow actively as hepatocytes in the
ubiquitous presence of both TGFß ligands and receptors has been unknown. We
hypothesized that microRNAs (miRNAs) might play a role in cell fate decisions in the liver.
miRNA profiling during late fetal development in the mouse identified miR-23b cluster …