The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism
JMM Den Haan, LM Meadows, W Wang, J Pool… - Science, 1998 - science.org
JMM Den Haan, LM Meadows, W Wang, J Pool, E Blokland, TL Bishop, C Reinhardus…
Science, 1998•science.orgThe minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which
mismatching is correlated with the development of severe graft versus host disease (GvHD)
after human leukocyte antigen–identical bone marrow transplantation. HA-1 was found to be
a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1–negative allelic
counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family
analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation …
mismatching is correlated with the development of severe graft versus host disease (GvHD)
after human leukocyte antigen–identical bone marrow transplantation. HA-1 was found to be
a nonapeptide derived from an allele of the KIAA0223 gene. The HA-1–negative allelic
counterpart encoded by KIAA0223 had one amino acid difference from HA-1. Family
analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation …
The minor histocompatibility antigen (mHag) HA-1 is the only known mHag for which mismatching is correlated with the development of severe graft versus host disease (GvHD) after human leukocyte antigen–identical bone marrow transplantation. HA-1 was found to be a nonapeptide derived from an allele of the KIAA0223gene. The HA-1–negative allelic counterpart encoded byKIAA0223 had one amino acid difference from HA-1. Family analysis with HA-1 allele-specific polymerase chain reaction showed an exact correlation between this allelic polymorphism and the HA-1 phenotype. HA-1 allele typing of donor and recipient should improve donor selection and allow the determination of bone marrow transplantation recipients with high risk for HA-1–induced GvHD development.
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