5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats
K Okamoto, H Imbe, Y Morikawa, M Itoh, M Sekimoto… - Pain, 2002 - Elsevier
One of the major serotonin (5-HT) receptor subtypes expressed in the rat dorsal root
ganglion (DRG) neurons is the 5-HT2A receptor. We have previously shown that 5-HT2A
receptors in the peripheral sensory terminals are responsible for 5-HT-induced pain and
hyperalgesia. In the present study, we characterized neurons expressing 5-HT2A receptors
in the rat DRG neurons by means of in situ hybridization, immunohistochemistry, reverse
transcription-polymerase chain reaction (RT-PCR) and behavioral tests. In situ hybridization …
ganglion (DRG) neurons is the 5-HT2A receptor. We have previously shown that 5-HT2A
receptors in the peripheral sensory terminals are responsible for 5-HT-induced pain and
hyperalgesia. In the present study, we characterized neurons expressing 5-HT2A receptors
in the rat DRG neurons by means of in situ hybridization, immunohistochemistry, reverse
transcription-polymerase chain reaction (RT-PCR) and behavioral tests. In situ hybridization …