Maternal gene expression profiling during pregnancy and preeclampsia in human peripheral blood mononuclear cells

A Rajakumar, T Chu, DE Handley, KD Bunce, B Burke… - Placenta, 2011 - Elsevier
Preeclampsia is a major obstetrical complication affecting maternal and fetal health. While it
is clear that there is a substantial placental contribution to preeclampsia pathogenesis, the
maternal contribution is less well characterized. We therefore performed a genome-wide
transcriptome analysis to explore disease-associated changes in maternal gene expression
patterns in peripheral blood mononuclear cells (PBMCs). METHODS: Preeclampsia was
defined as gestational hypertension, proteinuria and hyperurecimia. Total RNA was isolated …