[HTML][HTML] Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1

ML Hegde, CA Theriot, A Das, PM Hegde, Z Guo… - Journal of biological …, 2008 - ASBMB
The S phase-specific activation of NEIL1 and not of the other DNA glycosylases responsible
for repairing oxidatively damaged bases in mammalian genomes and the activation of
NEIL1 by proliferating cell nuclear antigen (PCNA) suggested preferential action by NEIL1 in
oxidized base repair during DNA replication. Here we show that NEIL1 interacts with flap
endonuclease 1 (FEN-1), an essential component of the DNA replication. FEN-1 is present
in the NEIL1 immunocomplex isolated from human cell extracts, and the two proteins …