[HTML][HTML] Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen: the potential for replication-associated repair of oxidized bases in …
H Dou, CA Theriot, A Das, ML Hegde… - Journal of Biological …, 2008 - ASBMB
NEIL1 and NEIL2 compose a family of DNA glycosylases that is distinct from that of the other
two DNA glycosylases, OGG1 and NTH1, all of which are involved in repair of oxidized
bases in mammalian genomes. That the NEIL proteins, unlike OGG1 and NTH1, are able to
excise base lesions from single-stranded DNA regions suggests their preferential
involvement in repair during replication and/or transcription. Previous studies showing S
phase-specific activation of NEIL1, but not NEIL2, suggested NEIL1 involvement in the …
two DNA glycosylases, OGG1 and NTH1, all of which are involved in repair of oxidized
bases in mammalian genomes. That the NEIL proteins, unlike OGG1 and NTH1, are able to
excise base lesions from single-stranded DNA regions suggests their preferential
involvement in repair during replication and/or transcription. Previous studies showing S
phase-specific activation of NEIL1, but not NEIL2, suggested NEIL1 involvement in the …