Apoptosis and autoimmunity

L Stuart, J Hughes - Nephrology Dialysis Transplantation, 2002 - academic.oup.com
L Stuart, J Hughes
Nephrology Dialysis Transplantation, 2002academic.oup.com
During normal tissue homeostasis, the rate of cell death is perfectly balanced by the rate of
production of new cells, resulting in a constant cell number. Apoptosis is a critically important
mechanism that facilitates deletion of unwanted or damaged cells in various circumstances,
including embryogenesis, inflammation and tissue healing. The purpose of this article is to
outline a 'darker side'of apoptosis since defects in the apoptotic cell death programme and
subsequent clearance of cellular corpses are implicated in the pathogenesis of clinically …
During normal tissue homeostasis, the rate of cell death is perfectly balanced by the rate of production of new cells, resulting in a constant cell number. Apoptosis is a critically important mechanism that facilitates deletion of unwanted or damaged cells in various circumstances, including embryogenesis, inflammation and tissue healing. The purpose of this article is to outline a ‘darker side’of apoptosis since defects in the apoptotic cell death programme and subsequent clearance of cellular corpses are implicated in the pathogenesis of clinically important autoimmune diseases such as systemic lupus erythematosus (SLE).
Oxford University Press