[HTML][HTML] Repair of oxidized bases in DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2
H Dou, S Mitra, TK Hazra - Journal of Biological Chemistry, 2003 - ASBMB
Repair of oxidatively damaged bases in the genome via the base excision repair pathway is
initiated with excision of these lesions by DNA glycosylases with broad substrate range. The
newly discovered human DNA glycosylases, NEIL1 and NEIL2, are distinct in structural
features and reaction mechanism from the previously characterized NTH1 and OGG1 but act
on many of the same substrates. However, NEIL2 shows a unique preference for excising
lesions from a DNA bubble, whereas NTH1 and OGG1 are only active with duplex DNA …
initiated with excision of these lesions by DNA glycosylases with broad substrate range. The
newly discovered human DNA glycosylases, NEIL1 and NEIL2, are distinct in structural
features and reaction mechanism from the previously characterized NTH1 and OGG1 but act
on many of the same substrates. However, NEIL2 shows a unique preference for excising
lesions from a DNA bubble, whereas NTH1 and OGG1 are only active with duplex DNA …