Mepolizumab does not alter levels of eosinophils, T cells, and mast cells in the duodenal mucosa in eosinophilic esophagitis

S Conus, A Straumann, E Bettler… - Journal of allergy and …, 2010 - jacionline.org
In the intestinal mucosa, an intense interplay between different subsets of T cells and
eosinophils exists, and it is believed that these mucosa-dwelling cells exhibit homeostatic
functions, including the modulation of local immune responses. For instance, eosinophils
might be important in antibacterial defense mechanisms. 4 Some lymphocyte subsets are
also known to be involved in the maintenance of intestinal barrier function as well as in the
suppression of chronic inflammation. 5 Similarly, gastrointestinal mast cells have been …