Interferon response factor 3 is essential for house dust mite–induced airway allergy
T Marichal, D Bedoret, C Mesnil, M Pichavant… - Journal of allergy and …, 2010 - Elsevier
BACKGROUND: Pattern-recognition receptors (PRRs) are critically involved in the
pathophysiology of airway allergy, yet most of the signaling pathways downstream of PRRs
implicated in allergic airway sensitization remain unknown. OBJECTIVE: We sought to study
the effects of genetic depletion of interferon response factor (IRF) 3 and IRF7, important
transcription factors downstream of various PRRs, in a murine model of house dust mite
(HDM)–induced allergic asthma. METHODS: We compared HDM-induced allergic immune …
pathophysiology of airway allergy, yet most of the signaling pathways downstream of PRRs
implicated in allergic airway sensitization remain unknown. OBJECTIVE: We sought to study
the effects of genetic depletion of interferon response factor (IRF) 3 and IRF7, important
transcription factors downstream of various PRRs, in a murine model of house dust mite
(HDM)–induced allergic asthma. METHODS: We compared HDM-induced allergic immune …