[HTML][HTML] IL-1β in eosinophil-mediated small intestinal homeostasis and IgA production
Y Jung, T Wen, MK Mingler, JM Caldwell, YH Wang… - Mucosal …, 2015 - Elsevier
Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina
propria, where their basal function remains largely unexplored. In this study, by examining
mice with a selective deficiency of systemic eosinophils (by lineage ablation) or GI
eosinophils (eotaxin-1/2 double deficient or CC chemokine receptor 3 deficient), we show
that eosinophils support immunoglobulin A (IgA) class switching, maintain intestinal mucus
secretions, affect intestinal microbial composition, and promote the development of Peyer's …
propria, where their basal function remains largely unexplored. In this study, by examining
mice with a selective deficiency of systemic eosinophils (by lineage ablation) or GI
eosinophils (eotaxin-1/2 double deficient or CC chemokine receptor 3 deficient), we show
that eosinophils support immunoglobulin A (IgA) class switching, maintain intestinal mucus
secretions, affect intestinal microbial composition, and promote the development of Peyer's …