[HTML][HTML] CKAP4/p63 is a receptor for the frizzled-8 protein-related antiproliferative factor from interstitial cystitis patients
TP Conrads, GM Tocci, BL Hood, CO Zhang… - Journal of Biological …, 2006 - ASBMB
Antiproliferative factor (APF) is a low molecular weight sialoglycopeptide that is secreted by
bladder cells from interstitial cystitis patients and is a potent inhibitor of both normal bladder
epithelial and bladder carcinoma cell proliferation. We hypothesized that APF may produce
its antiproliferative effects by binding to a transmembrane receptor. This study demonstrates
that cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor,
binds with high affinity to APF. The antiproliferative activity of APF is effectively inhibited by …
bladder cells from interstitial cystitis patients and is a potent inhibitor of both normal bladder
epithelial and bladder carcinoma cell proliferation. We hypothesized that APF may produce
its antiproliferative effects by binding to a transmembrane receptor. This study demonstrates
that cytoskeleton-associated protein 4/p63 (CKAP4/p63), a type II transmembrane receptor,
binds with high affinity to APF. The antiproliferative activity of APF is effectively inhibited by …