Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy
K Yamasaki, S Horiguchi, M Kurosaki, N Kunii… - Clinical …, 2011 - Elsevier
Vα24 natural killer T (NKT) cells have potent anti-tumor activity. We performed a phase II
clinical study in patients with head and neck squamous cell carcinoma (HNSCC) using ex
vivo expanded Vα24 NKT cells and α-galactosylceramide (αGalCer; KRN7000)-pulsed
antigen-presenting cells (APCs) to investigate the efficacy and induction of NKT cell-specific
immune responses. The subjects were 10 patients with locally recurrent and operable
HNSCC. One course of nasal submucosal administration of αGalCer-pulsed APCs and intra …
clinical study in patients with head and neck squamous cell carcinoma (HNSCC) using ex
vivo expanded Vα24 NKT cells and α-galactosylceramide (αGalCer; KRN7000)-pulsed
antigen-presenting cells (APCs) to investigate the efficacy and induction of NKT cell-specific
immune responses. The subjects were 10 patients with locally recurrent and operable
HNSCC. One course of nasal submucosal administration of αGalCer-pulsed APCs and intra …