Mild cognitive impairment in the elderly is associated with volume loss of the cholinergic basal forebrain region
K Muth, R Schönmeyer, S Matura, C Haenschel… - Biological …, 2010 - Elsevier
BACKGROUND: Cholinergic neurons within the basal forebrain are assumed to be an early
(preclinical) manifestation site of pathological changes in Alzheimer's disease (AD).
METHODS: We used morphometric magnetic resonance imaging (MRI) to detect and
quantify atrophic changes in the basal forebrain of subjects suffering from amnestic mild
cognitive impairment (aMCI). Three Tesla magnetic resonance (MR) data of 26 aMCI
patients, 46 cognitively normal elderly control subjects (CO), and 12 patients suffering from …
(preclinical) manifestation site of pathological changes in Alzheimer's disease (AD).
METHODS: We used morphometric magnetic resonance imaging (MRI) to detect and
quantify atrophic changes in the basal forebrain of subjects suffering from amnestic mild
cognitive impairment (aMCI). Three Tesla magnetic resonance (MR) data of 26 aMCI
patients, 46 cognitively normal elderly control subjects (CO), and 12 patients suffering from …