[HTML][HTML] First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms
T Borgegard, A Juréus, F Olsson, S Rosqvist… - Journal of Biological …, 2012 - ASBMB
γ-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production
of Alzheimer disease-related amyloid-β (Aβ) peptides. The Aβ42 peptide in particular plays
a pivotal role in Alzheimer disease pathogenesis and represents a major drug target.
Several γ-secretase modulators (GSMs), such as the nonsteroidal anti-inflammatory drugs
(R)-flurbiprofen and sulindac sulfide, have been suggested to modulate the Alzheimer-
related Aβ production by targeting the APP. Here, we describe novel GSMs that are selective …
of Alzheimer disease-related amyloid-β (Aβ) peptides. The Aβ42 peptide in particular plays
a pivotal role in Alzheimer disease pathogenesis and represents a major drug target.
Several γ-secretase modulators (GSMs), such as the nonsteroidal anti-inflammatory drugs
(R)-flurbiprofen and sulindac sulfide, have been suggested to modulate the Alzheimer-
related Aβ production by targeting the APP. Here, we describe novel GSMs that are selective …