The interaction of auranofin and buthionine sulfoximine blocks activation of human peripheral T lymphocytes
IAM Vint, BM Chain, JC Foreman - Cellular immunology, 1993 - Elsevier
We have previously demonstrated that auranofin, at nanomolar concentrations, enhances T
cell activation, as measured by IL-2 release and Tac expression. However, it is not clear how
enhanced T cell activation might be related to therapeutic value, since rheumatoid arthritis is
widely believed to be associated with overactivation of the immune response. In this study,
we show that the action of auranofin on T cell activation is dramatically influenced by the
glutathione levels of the responding cells. Under conditions of very low intracellular …
cell activation, as measured by IL-2 release and Tac expression. However, it is not clear how
enhanced T cell activation might be related to therapeutic value, since rheumatoid arthritis is
widely believed to be associated with overactivation of the immune response. In this study,
we show that the action of auranofin on T cell activation is dramatically influenced by the
glutathione levels of the responding cells. Under conditions of very low intracellular …