The redox proteome consists of reversible and irreversible covalent modifications that link
redox metabolism to biologic structure and function. These modifications, especially of Cys,
function at the molecular level in protein folding and maturation, catalytic activity, signaling,
and macromolecular interactions and at the macroscopic level in control of secretion and
cell shape. Interaction of the redox proteome with redox-active chemicals is central to
macromolecular structure, regulation, and signaling during the life cycle and has a central …