Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV
N Chomont, S DaFonseca… - Current opinion in …, 2011 - journals.lww.com
Current opinion in HIV and AIDS, 2011•journals.lww.com
These findings suggest that strategies aimed at reducing the pool of latently infected cells
should interfere with the survival pathways responsible for the long-term maintenance of
memory CD4+ T cells. Because memory CD4+ T cells are critical for appropriate immune
defense, targeted approaches are needed to interfere only with the long-term survival of
discrete fractions of memory T cells carrying proviral DNA.
should interfere with the survival pathways responsible for the long-term maintenance of
memory CD4+ T cells. Because memory CD4+ T cells are critical for appropriate immune
defense, targeted approaches are needed to interfere only with the long-term survival of
discrete fractions of memory T cells carrying proviral DNA.
Summary
These findings suggest that strategies aimed at reducing the pool of latently infected cells should interfere with the survival pathways responsible for the long-term maintenance of memory CD4+ T cells. Because memory CD4+ T cells are critical for appropriate immune defense, targeted approaches are needed to interfere only with the long-term survival of discrete fractions of memory T cells carrying proviral DNA.
Lippincott Williams & Wilkins