Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease
EJ Mufson, JM Li, T Sobreviela, JH Kordower - Neuroreport, 1996 - journals.lww.com
IN situ hybridization for TrkA mRNA was combined with quantitative optical densitometry to
evaluate whether the expression of this gene is altered within cholinergic basal forebrain
neurons (CBF) in Alzheimer's disease (AD). TrkA mRNA within individual nucleus basalis
neurons was significantly reduced (66%) in AD cases relative to aged controls. Reverse
transcription polymerase chain reaction quantitative analyses confirmed that TrkA mRNA
levels decreased markedly in AD. In contrast, expression of the gene coding for for the low …
evaluate whether the expression of this gene is altered within cholinergic basal forebrain
neurons (CBF) in Alzheimer's disease (AD). TrkA mRNA within individual nucleus basalis
neurons was significantly reduced (66%) in AD cases relative to aged controls. Reverse
transcription polymerase chain reaction quantitative analyses confirmed that TrkA mRNA
levels decreased markedly in AD. In contrast, expression of the gene coding for for the low …