Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
SD Ginsberg, MJ Alldred, SE Counts, AM Cataldo… - Biological …, 2010 - Elsevier
BACKGROUND: Endocytic dysfunction and neurotrophin signaling deficits may underlie the
selective vulnerability of hippocampal neurons during the progression of Alzheimer's
disease (AD), although there is little direct in vivo and biochemical evidence to support this
hypothesis. METHODS: Microarray analysis of hippocampal CA1 pyramidal neurons
acquired via laser capture microdissection was performed using postmortem brain tissue.
Validation was achieved using real-time quantitative polymerase chain reaction and …
selective vulnerability of hippocampal neurons during the progression of Alzheimer's
disease (AD), although there is little direct in vivo and biochemical evidence to support this
hypothesis. METHODS: Microarray analysis of hippocampal CA1 pyramidal neurons
acquired via laser capture microdissection was performed using postmortem brain tissue.
Validation was achieved using real-time quantitative polymerase chain reaction and …