[HTML][HTML] Proteolytic processing of the hepatitis B virus e antigen precursor: cleavage at two furin consensus sequences
F Messageot, S Salhi, P Eon, JM Rossignol - Journal of Biological …, 2003 - ASBMB
The Hepatitis B virus P22 protein is a nonstructural protein that is the precursor of the 17-
kDa secreted e antigen (HBeAg). The mature HBeAg is obtained after the removal of the C-
terminal region of P22, a process which involves a proprotein convertase. Our studies show
first that the protease could cleave P22 at the C-terminal side of Arg 167 or Arg 154 and
second, that the maturation process can be either done in one step or in two steps with the
generation of a processing intermediate (P20). Our data also demonstrate that the removal …
kDa secreted e antigen (HBeAg). The mature HBeAg is obtained after the removal of the C-
terminal region of P22, a process which involves a proprotein convertase. Our studies show
first that the protease could cleave P22 at the C-terminal side of Arg 167 or Arg 154 and
second, that the maturation process can be either done in one step or in two steps with the
generation of a processing intermediate (P20). Our data also demonstrate that the removal …