Cardiac myocyte-derived follistatin-like 1 prevents renal injury in a subtotal nephrectomy model
S Hayakawa, K Ohashi, R Shibata… - Journal of the …, 2015 - journals.lww.com
Heart disease contributes to the progression of CKD. Heart tissue produces a number of
secreted proteins, also known as cardiokines, which participate in intercellular and
intertissue communication. We recently reported that follistatin-like 1 (Fstl1) functions as a
cardiokine with cardioprotective properties. Here, we investigated the role of cardiac Fstl1 in
renal injury after subtotal nephrectomy. Cardiac-specific Fstl1-deficient (cFstl1-KO) mice and
wild-type mice were subjected to subtotal (5/6) nephrectomy. cFstl1-KO mice showed …
secreted proteins, also known as cardiokines, which participate in intercellular and
intertissue communication. We recently reported that follistatin-like 1 (Fstl1) functions as a
cardiokine with cardioprotective properties. Here, we investigated the role of cardiac Fstl1 in
renal injury after subtotal nephrectomy. Cardiac-specific Fstl1-deficient (cFstl1-KO) mice and
wild-type mice were subjected to subtotal (5/6) nephrectomy. cFstl1-KO mice showed …