Safety of long-term interruption of successful antiretroviral therapy: the ATHENA cohort study
FWNM Wit, DH Blanckenberg, K Brinkman, JM Prins… - Aids, 2005 - journals.lww.com
FWNM Wit, DH Blanckenberg, K Brinkman, JM Prins, ME van der Ende, MME Schneider…
Aids, 2005•journals.lww.comWe studied the dynamics of CD4 cell counts after the interruption of virologically successful
highly active antiretroviral therapy (HAART) in 139 patients. Changes in CD4 cell counts
during HAART interruption followed a biphasic pattern: an initial rapid decline during the first
month followed by a slow decrease. During 48 weeks of follow-up mean CD4 cell counts
remained just above the mean pre-HAART level. This limits the feasibility of structured
treatment interruptions for patients with low nadir CD4 cell counts.
highly active antiretroviral therapy (HAART) in 139 patients. Changes in CD4 cell counts
during HAART interruption followed a biphasic pattern: an initial rapid decline during the first
month followed by a slow decrease. During 48 weeks of follow-up mean CD4 cell counts
remained just above the mean pre-HAART level. This limits the feasibility of structured
treatment interruptions for patients with low nadir CD4 cell counts.
Abstract
We studied the dynamics of CD4 cell counts after the interruption of virologically successful highly active antiretroviral therapy (HAART) in 139 patients. Changes in CD4 cell counts during HAART interruption followed a biphasic pattern: an initial rapid decline during the first month followed by a slow decrease. During 48 weeks of follow-up mean CD4 cell counts remained just above the mean pre-HAART level. This limits the feasibility of structured treatment interruptions for patients with low nadir CD4 cell counts.
Lippincott Williams & Wilkins