Immune reconstitution of the female reproductive tract of humanized BLT mice and their susceptibility to human immunodeficiency virus infection
R Olesen, A Wahl, PW Denton, JV Garcia - Journal of reproductive …, 2011 - Elsevier
An HIV-1 vaccine capable of providing sterilizing immunity from vaginal infection would
reduce the spread of HIV-1 to women. Unfortunately, only one of the four HIV-1 vaccine
clinical trials has demonstrated any level of protection (31%) against HIV-1 transmission.
Additionally, only one topical microbicide clinical trial has reported an overall reduction in
HIV-1 transmission (39%). Developing even more effective vaccines and microbicides will
require a better understanding of the key events involved in HIV-1 infection and …
reduce the spread of HIV-1 to women. Unfortunately, only one of the four HIV-1 vaccine
clinical trials has demonstrated any level of protection (31%) against HIV-1 transmission.
Additionally, only one topical microbicide clinical trial has reported an overall reduction in
HIV-1 transmission (39%). Developing even more effective vaccines and microbicides will
require a better understanding of the key events involved in HIV-1 infection and …